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KMID : 0861020130280020009
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Korea Journal of Herbology
2013 Volume.28 No. 2 p.9 ~ p.15
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Effects of the ethanol extract of Codonopsis Pilosulae Radix on ovalbumin-induced allergic responses in mice
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강석용:Kang Seok-Yong
정진기:Jung Jin-Ki/이상국:Lee Sang-Kook/이승호:Lee Seung-Ho/박용기:Park Yong-Kee
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Abstract
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Objectives : The root of Codonopsis pilosula (Fr.) Nannf. (Codonopsis Pilosulae Radix) has been traditionally
used as a oriental medicine with an anti-thrombotic, antidiabetic, anticancer, and anti-gastric ulcer effects and
immunological adjuvant. In this study, we investigated the effect of 70% ethanol extract of Codonopsis Pilosulae
Radix (CPR-E) on ovalbumin (OVA)-induced allergic responses in mice.
Methods : Mice were sensitized (1, 8, and 15 days) with OVA and airway challenged(22, 24, 26, 28, and 30
days) to induced allergic responses. CPR-E extract at doses of 50 and 100 ㎎/㎏/body weight was orally
administered from days 21 to 30 consecutively. The levels of allergic mediators such as histamine, OVA-specific
immunoglobulin (Ig) E, and Th1/Th2 cytokines such as IFN-γ and IL-4 were measured in the sera of mice by
ELISA. The histological change of lung tissue was observed by hematoxylin and eosin (H&E) staining.
Results : CPR-E extract significantly decreased the serum levels of histamine, OVA-specific IgE, and IL-4
compared with those of OVA control group, but significantly increased the serum level of IFN-γ. Based on
H&E staining, CPR-E extract inhibited the infiltration of inflammatory cells into lung tissues with histological
changes.
Conclusions : These results indicate that CPR-E extract has anti-inflammatory and anti-allergic responses
through regulating the cytokine balance, suggesting that the extract may be useful for the treatment of allergic
inflammatory diseases such as bronchial asthma and allergic rhinitis.
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KEYWORD
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Codonopsis Pilosulae Radix, ovalbumin, allergic response, inflammation, Th1/Th2 cytokine
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